Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities

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junho 3, 2019

Ting Wu, Meng Wang, Wenfang Wu, Qianxuan Luo, Liping Jiang, Huai Tao,  Meichun Deng

Journal of Venomous Animals and Toxins including Tropical Diseases 2019;25:e146318
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100203&lng=en&nrm=iso&tlng=en | © The Author(s). 2019
Received: June 13, 2018 | Accepted: November 15, 2018 | Published: June 3, 2019

ABSTRACT

Background

Spider venoms are known to contain proteins and polypeptides that perform various functions including antimicrobial, neurotoxic, analgesic, cytotoxic, necrotic, and hemagglutinic activities. Currently, several classes of natural molecules from spider venoms are potential sources of chemotherapeutics against tumor cells. Some of the spider peptide toxins produce lethal effects on tumor cells by regulating the cell cycle, activating caspase pathway or inactivating mitochondria. Some of them also target the various types of ion channels (including voltage-gated calcium channels, voltage-gated sodium channels, and acid-sensing ion channels) among other pain-related targets. Herein we review the structure and pharmacology of spider-venom peptides that are being used as leads for the development of therapeutics against the pathophysiological conditions including cancer and pain.

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KEYWORDS

spider venom peptides
antitumor
pain
drug candidates
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