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Discovering candidate molecules from animal toxins with potential application in biotechnology

Guest editors: Suely V. Sampaio, Eliane C. Arantes and Marco A. Sartim
Discovering candidate molecules from animal toxins with potential application in biotechnology


Envenoming caused by venomous and poisonous animals is considered an important public health threat in tropical countries due to their wide distribution and the high occurrence of accidents in urban and rural areas. This health issue has been encouraging the scientific community to investigate the clinical aspects of envenoming and to search for more effective antivenom therapies. Moreover, the growing concern in discovering novel molecules with potential application as therapeutic agents and/or as biotechnological tools has increased the interest in exploring venoms as natural sources of pharmacologically active compounds. The advances in high throughput approaches in Toxinology, such as the genomic, transcriptomic and proteomic techniques, have unveiled a remarkable functional and structural complexity in venom and poison composition, revealing a variety of molecules that target proteins, receptors, or ion channels with distinct potency and specificity.

Considering the relevance of this issue, the Journal of Venomous Animals and Toxins including Tropical Diseases is calling for papers in a thematic series on “Discovering candidate molecules from animal toxins with potential application in biotechnology” edited by Dr. Suely V. Sampaio, Dr. Eliane C. Arantes and Dr. Marco A. Sartim (University of São Paulo, Brazil). The series will accept research approaching “omics” analysis, structural and biological studies, and biotechnological application comprising venoms and/or isolated toxins from animals.

The submission deadline is July 31, 2018.

Manuscripts should be formatted according to our submission guidelines and submitted via the online submission system. In the submission system, please make sure the correct collection title is chosen from the additional information tab. Please also indicate clearly in the covering letter that the manuscript is to be considered for the “Discovering candidate molecules from animal toxins with potential application in biotechnology” series.

If you would like to enquiry about the suitability of a manuscript for consideration, please email a pre-submission enquiry to editorial@jvat.org.br.


Research  |  Cytotoxic and pro-apoptotic action of MjTX-I, a phospholipase A2 isolated from Bothrops moojeni snake venom, towards leukemic cells
Rogério Bodini Benati, Tássia Rafaela Costa, Maira da Costa Cacemiro, Suely Vilela Sampaio, Fabíola Attié de Castro and Sandra Mara Burin
>> Full Text       >> PDF

Review  |  Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties
Marco Aurélio Sartim, Danilo Luccas Menaldo and Suely Vilela Sampaio
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Research  |  Kinetic investigations and stability studies of two Bothrops L-amino acid oxidases
Tássia R. Costa, Sante E. I. Carone, Luiz F. F. Tucci, Danilo L. Menaldo, Nathalia G. Rosa-Garzon, Hamilton Cabral and Suely V. Sampaio
>> Full Text       >> PDF

Research  |  Deep sequencing analysis of toad Rhinella schneideri skin glands and partial biochemical characterization of its cutaneous secretion
Priscila Yumi Tanaka Shibao, Camila Takeno Cologna, Romualdo Morandi-Filho, Gisele Adriano Wiezel, Patricia Tiemi Fujimura, Carlos Ueira-Vieira and Eliane Candiani Arantes
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Research  |  Cytotoxic and inflammatory potential of a phospholipase A2 from Bothrops jararaca snake venom
Rafhaella C. A. Cedro, Danilo L. Menaldo, Tássia R. Costa, Karina F. Zoccal, Marco A. Sartim, Norival A. Santos-Filho, Lúcia H. Faccioli and Suely V. Sampaio
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Research  |  Purification and enzymatic characterization of a novel metalloprotease from Lachesis muta rhombeata snake venom
Francielle Almeida Cordeiro, Bárbara Marques Coutinho, Gisele Adriano Wiezel, Karla de Castro Figueiredo Bordon, Cristiane Bregge-Silva, Nathalia Gonsales Rosa-Garzon, Hamilton Cabral, Beatrix Ueberheide and Eliane Candiani Arantes
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Research  |  Cell migration inhibition activity of a non-RGD disintegrin from Crotalus durissus collilineatus venom
Isadora Sousa de Oliveira, Rafaella Varzoni Manzini, Isabela Gobbo Ferreira, Iara Aimê Cardoso, Karla de Castro Figueiredo Bordon, Ana Rita Thomazela Machado, Lusânia Maria Greggi Antunes, José Cesar Rosa and Eliane Candiani Arantes
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Research  |  BjussuLAAO-II induces cytotoxicity and alters DNA methylation of cell-cycle genes in monocultured/co-cultured HepG2 cells
Ana Rita Thomazela Machado, Alexandre Ferro Aissa, Diego Luis Ribeiro, Rui Seabra Ferreira Jr, Suely Vilela Sampaio and Lusânia Maria Greggi Antunes
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Research  |  Functional and biological insights of rCollinein-1, a recombinant serine protease from Crotalus durissus collilineatus
Johara Boldrini-França, Ernesto Lopes Pinheiro-Junior and Eliane Candiani Arantes
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Research  |  Subproteome of Lachesis muta rhombeata venom and preliminary studies on LmrSP-4, a novel snake venom serine proteinase
Gisele A Wiezel, Karla CF Bordon, Ronivaldo R Silva, Mário SR Gomes, Hamilton Cabral, Veridiana M Rodrigues, Beatrix Ueberheide and Eliane C Arantes
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Review  |  Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression
Isadora S Oliveira, Isabela G Ferreira, Gabriel M Alexandre-Silva, Felipe A Cerni, Caroline M Cremonez, Eliane C Arantes, Umberto Zottich and Manuela B Pucca
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Research  |  Proteome of fraction from Tityus serrulatus venom reveals new enzymes and toxins
Fernanda Gobbi Amorim, Heloisa Tavoni Longhim, Camila Takeno Cologna, Michel Degueldre, Edwin De Pauw, Loïc Quinton and Eliane Candiani Arantes
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Research  |  Assessment of neuropharmacological potential of low molecular weight components extracted from Rhinella schneideri toad poison
Mateus Amaral Baldo, Alexandra Olimpio Siqueira Cunha, Lívea Dornela Godoy, José Luiz Liberato, Juliana Sakamoto Yoneda, Elisa Correa Fornari-Baldo, Pietro Ciancaglini, Wagner Ferreira dos Santos and Eliane Candiani Arantes
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Research  |  Neuroprotective properties of RT10, a fraction isolated from Parawixia bistriata spider venom, against excitotoxicity injury in neuron-glia cultures
Eduardo Octaviano Primini, José Luiz Liberato, Andreia Cristina Karklin Fontana and Wagner Ferreira dos Santos
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Review  |  Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities
Ting Wu, Meng Wang, Wenfang Wu, Qianxuan Luo, Liping Jiang, Huai Tao and Meichun Deng
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