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Animal toxins: exploring novel bioactive compounds from toads, snakes and scorpions

Guest editors: Suely Vilela, Eliane Candiane Arantes and Danilo L. Menaldo
Animal toxins: exploring novel bioactive compounds from toads, snakes and scorpions


Given its huge biodiversity, which includes a great amount of venomous and poisonous animal species, Brazil is well-known for its toxinological research. In this special collection published in Journal of Venomous Animals and Toxins including Tropical Diseases, we present a series of studies which have been carried out by a high-profile group of Brazilian researchers from the Research Support Center on Animal Toxins (NAP-TOXAN-USP) at University of São Paulo in Ribeirão Preto, and have been funded by the São Paulo Research Foundation (Fapesp).

These studies describe new compounds from toad poison and snake and scorpion venoms using different approaches for their isolation and structural and functional characterization, aiming at the discovery of new candidate molecules. We are delighted to publish them as a special collection and believe it will be of interest for all involved not only with Toxinology but also with drug discovery and biotechnology development.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Editor declares no competing interests.


Research  |  Partial purification and functional characterization of Ts19 Frag-I, a novel toxin from Tityus serrulatus scorpion venom
Priscila C. Lima, Karla C. F. Bordon, Manuela B. Pucca, Felipe A. Cerni, Karina F. Zoccal, Lucia H. Faccioli and Eliane C. Arantes 
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Research  |  In vitro activity of phospholipase A2 and of peptides from Crotalus durissus terrificus venom against amastigote and promastigote forms of Leishmania (L.) infantum chagasi
Gustavo A. C. Barros, Andreia V. Pereira, Luciana C. Barros, Airton Lourenço Jr, Sueli A. Calvi, Lucilene D. Santos, Benedito Barraviera and Rui Seabra Ferreira Jr.
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Research   |  Immunomodulatory activity of Tityus serrulatus scorpion venom on human T lymphocytes
Andrea Casella-Martins, Lorena R. Ayres, Sandra M. Burin, Fabiana R. Morais, Juliana C. Pereira, Lucia H. Faccioli, Suely V. Sampaio, Eliane C. Arantes, Fabiola A. Castro and Luciana S. Pereira-Crott 
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Research   |  Antitumor potential of the myotoxin BthTX-I from Bothrops jararacussu snake venom: evaluation of cell cycle alterations and death mechanisms induced in tumor cell lines
Cássio Prinholato da Silva, Tássia R. Costa, Raquel M. Alves Paiva, Adélia C. O. Cintra, Danilo L. Menaldo, Lusânia M. Greggi Antunes and Suely V. Sampaio
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Review   |   Snake venom galactoside-binding lectins: a structural and functional overview
Marco A. Sartim and Suely V. Sampaio
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Short report   |   First serine protease inhibitor isolated from Rhinella schneideri poison
Priscila Y. T. Shibao, Fernando A. P. Anjolette, Norberto P. Lopes and Eliane C. Arantes 
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Research   |   Bothrops snake venoms and their isolated toxins, an L-amino acid oxidase and a serine protease, modulate human complement system pathways
Lorena Rocha Ayres, Alex dos Reis Récio, Sandra Mara Burin, Juliana Campos Pereira, Andrea Casella Martins, Suely Vilela Sampaio, Fabíola Attié de Castro and Luciana Simon Pereira-Crott 
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Research   |   Purification procedure for the isolation of a P-I metalloprotease and an acidic phospholipase A2 from Bothrops atrox snake venom
Danilo L. Menaldo, Anna L. Jacob-Ferreira, Carolina P. Bernardes, Adélia C. O. Cintra and Suely V. Sampaio
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Research   |   Bordonein-L, a new L-amino acid oxidase from Crotalus durissus terrificus snake venom: isolation, preliminary characterization and enzyme stability
Karla C. F. Bordon, Gisele A. Wiezel, Hamilton Cabral and Eliane C. Arantes
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Research   |   Biological characterization of compounds from Rhinella schneideri poison that act on the complement system
Fernando A. P. Anjolette, Flávia P. Leite, Karla C. F. Bordon, Ana Elisa C. S. Azzolini, Juliana C. Pereira, Luciana S. Pereira-Crott and Eliane C. Arantes
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Review   |   Arachnids of medical importance in Brazil: main active compounds present in scorpion and spider venoms and tick saliva
Francielle A. Cordeiro, Fernanda G. Amorim, Fernando A. P. Anjolette and Eliane C. Arantes
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